A hulking, full-tower PC is always your best option if you want room for multiple graphics cards, general upgrades, or all the terabytes of storage you could ever reasonably afford. But these days, you don’t necessarily need one if you want a powerful PC that can handle editing high-def or 4K video, playing new AAA games at 4K, and powering virtual-reality (VR) headsets.
As more and more PC enthusiasts and boutique-PC builders have shown interest in compact performance systems, many case makers have offered up comparatively compact chassis that have room for midsize or even full-size graphics cards. For instance, the shoebox-shaped SilverStone Sugo SG12 has room enough for a graphics card over a foot long. That means the largest and most powerful cards available, such as the Nvidia GeForce GTX 1080 Ti or AMD’s Radeon RX Vega 64, should have plenty of clearance in that case.
The similarly compact Cougar QBX Ultra Compact Pro Gaming Mini-ITX Case has an even smaller footprint, and it has nearly 14 inches of clearance for beastly graphics cards. Just note that specialized compact cases like these usually require a MicroATX or Mini-ITX motherboard, rather than a more standard (and often less expensive) full-size ATX motherboard. Their unusual proportions mean that they may be able to take big video cards, but not big mainboards.